ABOUT SERO

Translating Scientific Discovery into Targeted Therapeutics

Sero Pharmaceuticals is a clinical-stage biotechnology company developing highly selective serotonergic therapies to address diseases with significant unmet needs in neuropsychiatric and vascular disorders.
 
Founded on discoveries from the Vanderbilt University Warren Center, our approach combines cutting-edge receptor pharmacology with deep drug development expertise to advance targeted therapies designed to improve safety, specificity, and patient outcomes.

OUR TEAM

Backed by Breakthrough Science and Leaders in the Field

Sero’s science is built on world-class research in GPCR biology, mechanobiology, and translational vascular medicine.

Our founding team brings together experts from Vanderbilt University with deep experience in drug discovery, immunology, and clinical development.

Sero Pharmaceuticals
Josh Nickols, PhD, CEO, Sero Pharmaceuticals
Josh Nickols, PhD

Chief Executive Officer
Sero Pharmaceuticals

Tracy Frech, MD, MS, Chief Medical Officer, Sero Pharmaceuticals
Tracy Frech, MD, MS

Chief Medical Officer
Sero Pharmaceuticals

Craig Lindsley, PhD
Craig Lindsley, PhD

University Professor of Pharmacology, Biochemistry, and Chemistry

William K. Warren, Jr. Chair in Medicine
Executive Director, Warren Center for Neuroscience Drug Discovery

David Merryman, PhD
David Merryman, PhD

Walters Family Professor

Professor of Biomedical Engineering, Pharmacology, Medicine, and Pediatrics

SCIENTIFIC ADVISORS

Bryan Roth, MD, PhD, is a professor of pharmacology at UNC Chapel Hill and a leading expert in GPCR biology and drug discovery, known for developing chemogenetic tools like DREADDs. His work has advanced the understanding of neuropsychiatric drug mechanisms and off-target effects.

Jorg Distler, MD, PhD, is a clinical pharmacologist and researcher specializing in translational medicine and early-phase drug development, with a focus on immunology and inflammatory diseases. He has held leadership roles in academic and pharmaceutical settings, bridging bench research and clinical application.

Vanderbilt Institute for Therapeutic Advances
Warren Center for Neuroscience Drug Discovery at Vanderbilt University
Sero Pharmaceuticals
Sero Pharmaceuticals | About Us
Sero Pharmaceuticals
"Vanderbilt brings deep expertise in GPCR and serotonin biology, with a proven track record of discovering potent serotonin receptor modulators, including 5HT2B antagonists. This foundation in pharmacology and translational modeling helps reduce early development risk and positions the platform to support a scalable portfolio of targeted serotonergic therapies."
Josh Nickols, PhD, CEO, Sero Pharmaceuticals
Josh Nickols, PhD
CEO, Sero Pharamaceuticals

OUR DRUG DISCOVERY PARTNER

Warren Center & VITA

The Warren Center for Neuroscience Drug Discovery (WCNDD) was established with a major endowment from the William K. Warren Foundation to translate academic neuroscience into viable drug programs. It grew into a ~100-scientist, pharma-grade discovery group with strengths in medicinal chemistry, pharmacology, DMPK, and in vivo models. Its track record is uncommon for academia, with dozens of industry partnerships, hundreds of patents and publications, and multiple CNS programs advanced into Phase I trials.
 
Announced in 2026, VITA builds directly on this model and extends it beyond neuroscience into oncology, cardiovascular, metabolic disease, and antimicrobial resistance. Led by Craig Lindsley, VITA maintains its focus on translational rigor and early de-risking while broadening its scope across therapeutic areas.
 
The platform is supported by Vanderbilt’s High-Throughput Screening (V-HTS) Core, which provides automated screening, high-content imaging, and access to a ~350,000-compound small-molecule library. The group supports the full early discovery workflow, from assay development through screening, hit triage, and data analysis.

CONNECT WITH US

Collaborate With the Team Behind Sero

Sero Pharmaceuticals collaborates with investors, research partners, and the scientific community to develop new approaches to complex neurological and vascular diseases. Connect with us to discover shared value, access to innovative research, and opportunities for impactful collaboration.

Josh Nickols, PhD

Chief Executive Officer

Dr. Nickols is a biotech/medtech executive and neuroscientist with expertise in company formation, translational science, and venture-backed therapeutics.

He has led multiple life science companies from early-stage development through strategic partnerships and acquisitions. Graduate of Vanderbilt PhD (Neuroscience) and MBA programs.

Tracy Frech, MD, MS

Chief Medical Officer

Dr. Frech is a rheumatologist and clinical researcher at Vanderbilt University specializing in systemic sclerosis and Raynaud’s phenomenon. Her work centers on immune-mediated vasculopathy and biomarker-driven approaches to rare autoimmune diseases.

Craig Lindsley, PhD

University Professor of Pharmacology, Biochemistry, and Chemistry

William K. Warren, Jr. Chair in Medicine

Executive Director, Warren Center for Neuroscience Drug Discovery

Dr. Lindsley is a leading medicinal chemist with extensive experience in drug discovery, particularly in neuroscience and GPCR-targeted therapeutics.

DaviD Merryman, PhD

Walters Family Professor

Professor of Biomedical Engineering, Pharmacology, Medicine, and Pediatrics

Dr. Merryman’s research group focuses on cardiovascular mechanobiology and fibrotic diseases.